Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings

Optimizing cutting parameters in hard turning of AISI 52100 steel using TOPSIS approach

In the present work optimization of cutting parameters is performed while hard turning of AISI 52100 steel with polycrystalline cubic boron nitride (PCBN) tools using Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). Experiments are planned and conducted based on Center Composite Rotatable Design (CCD) of the Response Surface Method (RSM). Cutting speed, feed, depth of cut, nose radius and negative rake angle are considered as input parameters. In this study machining force (F) and surface roughness (Ra) are measured during the experiment. Analysis of variance (ANOVA) is deployed to determine the influence of process parameters. Obtained optimal parameters are speed 200 rpm, feed 0.1 mm/rev, depth of cut 0.8 mm, nose radius 1.2 mm and negative rake angle 45º